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Richard Murray, California Institute of Technology

Systems, Controls and Robotics Seminar

Feedback and Control in Biological Circuit Design

Friday, March 12, 3:30pm
403 EEB


Biological systems make use of feedback in an extraordinary number of ways, on scales ranging from molecules to cells to organisms to ecosystems. In this talk I will discuss the use of concepts from control and dynamical systems in the analysis and design of biological feedback circuits at the molecular level. Recent results include the use of intrinsic noise for system identification in transcriptional regulatory networks, development of an in vitro circuit for regulating the rates of transcription of two independent genetic sequences, and design of dynamics of for an in vivo oscillator using transcriptional delay. Using these results as examples, I will discuss some of the open problems and research challenges in the area feedback control using biological circuits.

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Richard M. Murray received the B.S. degree in Electrical Engineering from California Institute of Technology in 1985 and the M.S. and Ph.D. degrees in Electrical Engineering and Computer Sciences from the University of California, Berkeley, in 1988 and 1991, respectively. He is currently the Thomas E. and Doris Everhart Professor of Control and Dynamical Systems. Murray's research is in the application of feedback and control to mechanical, information, and biological systems. Current projects include integration of control, communications, and computer science in multi-agent systems, information dynamics in networked feedback systems, analysis of insect flight control systems, and biological circuit design.

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